Articles

The purine path to chemotherapy

Science  07 Apr 1989:
Vol. 244, Issue 4900, pp. 41-47
DOI: 10.1126/science.2649979

Abstract

Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirus infections (acyclovir), and for the prevention of organ transplant rejection (azathioprine).

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