Reports

Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum

Science  09 Jun 1989:
Vol. 244, Issue 4909, pp. 1184-1186
DOI: 10.1126/science.2658061

Abstract

The malaria parasite Plasmodium falciparum contains at least two genes related to the mammalian multiple drug resistance genes, and at least one of the P. falciparum genes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.

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