Reports

Was adenine the first purine?

Science  08 Sep 1989:
Vol. 245, Issue 4922, pp. 1102-1104
DOI: 10.1126/science.11538344

Abstract

Oligomerization of HCN (1 molar) in the presence of added formaldehyde (0.5 molar) produced an order of magnitude more 8-hydroxymethyladenine than adenine or any other biologically significant purine. This result suggests that on the prebiotic Earth, nucleoside analogs may have been synthesized directly in more complex mixtures of HCN with other aldehydes.

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