Toward Protein Tertiary Structure Recognition by Means of Associative Memory Hamiltonians

Science  20 Oct 1989:
Vol. 246, Issue 4928, pp. 371-373
DOI: 10.1126/science.246.4928.371


The statistical mechanics of associative memories and spin glasses suggests ways to design Hamiltonians for protein folding. An associative memory Hamiltonian based on hydrophobicity patterns is shown to have a large capacity for recall and to be capable of recognizing tertiary structure for moderately variant sequences.