Reports

Toward Protein Tertiary Structure Recognition by Means of Associative Memory Hamiltonians

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Science  20 Oct 1989:
Vol. 246, Issue 4928, pp. 371-373
DOI: 10.1126/science.246.4928.371

Abstract

The statistical mechanics of associative memories and spin glasses suggests ways to design Hamiltonians for protein folding. An associative memory Hamiltonian based on hydrophobicity patterns is shown to have a large capacity for recall and to be capable of recognizing tertiary structure for moderately variant sequences.