Reports

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

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Science  19 Jan 1990:
Vol. 247, Issue 4940, pp. 322-324
DOI: 10.1126/science.2296722

Abstract

In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.