Reports

Binding of GAP to activated PDGF receptors

Science  30 Mar 1990:
Vol. 247, Issue 4950, pp. 1578-1581
DOI: 10.1126/science.2157284

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Abstract

The ras proto-oncogene products appear to relay intracellular signals via the Ras guanosine triphosphatase (GTPase) activator protein, GAP. In dog epithelial cells expressing human platelet-derived growth factor (PDGF) receptors, binding of PDGF caused approximately one-tenth of the total GAP molecules to complex with the receptor. Studies with mutant PDGF receptors showed that maximum association required both receptor kinase activity and phosphorylatable tyrosine residues at both the identified sites of receptor autophosphorylation.

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