Corrections and Clarifications


Science  22 Jun 1990:
Vol. 248, Issue 4962, pp. 1473
DOI: 10.1126/science.1473-a


In the report "Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa" by L. Waxman et al. (4 May, p. 593), the second sentence of the caption of figure 2 was printed incorrectly. It should have read, "Determination of the Intrinsic Ki was done by fitting the observed data (•) with nonlinear regression analysis to the ratio of inhibited velocity (vi) to uninhibited velocity (Vo) described by the equation Vi/Vo = [Et - It K*i] + [(It + K*i - Et)2 + 4KiEt]1/2/2Et derived by Morrison for tight-binding inhibition (7) (solid line), where Et and It are the total amount of enzyme and inhibitor, respectively, included in the assay."