Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver

Science  21 Dec 1990:
Vol. 250, Issue 4988, pp. 1732-1735
DOI: 10.1126/science.1702902


Transcription of the mouse alpha-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation site of the alpha-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.

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