DNA: a model compound for solution studies of macromolecules

Science  22 Feb 1991:
Vol. 251, Issue 4996, pp. 893-898
DOI: 10.1126/science.2000490


Well-defined, monodisperse, homologous series of oligonucleotides and DNA restriction fragments may now be produced and used as models of rigid and semirigid rodlike molecules in solution. Information from optical experiments on these model systems aids in the formulation and testing of theories of macromolecular dynamics in both dilute and concentrated solution.