Reports

Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR

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Science  29 Mar 1991:
Vol. 251, Issue 5001, pp. 1597-1600
DOI: 10.1126/science.2011739

Abstract

Human immunodeficiency virus type 1 (HIV-1) gene expression is activated by Tat, a virally encoded protein. Tat trans-activation requires viral (trans-activation--responsive; TAR) RNA sequences located in the R region of the long terminal repeat (LTR). Existing evidence suggests that Tat probably cooperates with cellular factors that bind to TAR RNA in the overall trans-activation process. A HeLa complementary DNA was isolated and characterized that encodes a TAR RNA-binding protein (TRBP). TRBP activated the HIV-1 LTR and was synergistic with Tat function.