Articles

Tumor suppressor genes

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Science  22 Nov 1991:
Vol. 254, Issue 5035, pp. 1138-1146
DOI: 10.1126/science.1659741

Abstract

For the past decade, cellular oncogenes have attracted the attention of biologists intent on understanding the molecular origins of cancer. As the present decade unfolds, oncogenes are yielding their place at center stage to a second group of actors, the tumor suppressor genes, which promise to teach us equally important lessons about the molecular mechanisms of cancer pathogenesis.