Intracellular signaling by 14-hydroxy-4,14-retro-retinol

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Science  13 Dec 1991:
Vol. 254, Issue 5038, pp. 1654-1656
DOI: 10.1126/science.1749937


In mammals, retinol is the precursor for retinoids, which affect various aspects of morphogenesis and development. However, B lymphocytes, although retinol-dependent, do not use retinoic acid as mediator. Retinol is metabolized by B lymphocytes and other cell lines to optically active 14-hydroxy-4,14-retro-retinol; it is this compound that mediates the growth control. Thus another second messenger molecule, in addition to retinoic acid and retinal, is derived from retinol.