Role of CD8+ T Cells in Murine Experimental Allergic Encephalomyelitis

Science  22 May 1992:
Vol. 256, Issue 5060, pp. 1213-1215
DOI: 10.1126/science.256.5060.1213


The course of experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis, is affected by immunoregulatory T lymphocytes. When animals are immunized with encephalitogenic peptide of myelin basic protein and recover from the first episode of EAE, they become resistant to a second induction of this disease. Animals depleted of CD8+ T cells by antibody-mediated clearance were used to examine the role of CD8+ T cells in EAE. These cells were found to be major participants in the resistance to a second induction of EAE but were not essential for spontaneous recovery from the first episode of the disease.

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