Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

Science  21 Aug 1992:
Vol. 257, Issue 5073, pp. 1134-1138
DOI: 10.1126/science.257.5073.1134


Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.

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