Articles

What if Minkowski had been ageusic? An alternative angle on diabetes

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Science  30 Oct 1992:
Vol. 258, Issue 5083, pp. 766-770
DOI: 10.1126/science.1439783

Abstract

Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance and hyperglycemia might be more readily understood if viewed in the context of underlying abnormalities of lipid metabolism.