Selectins: interpreters of cell-specific carbohydrate information during inflammation

Science  06 Nov 1992:
Vol. 258, Issue 5084, pp. 964-969
DOI: 10.1126/science.1439808


Although a bewildering array of cell surface carbohydrate structures have been described, the physiological relevance of any of these complex molecules has often eluded biologists. A family of cell surface glycoproteins, the "selectins," has a characteristic ability to use some of these carbohydrate structures in adhesive mechanisms that help localize leukocytes to regions of inflammation. This article will review the biology of these carbohydrate-binding adhesive proteins and discuss the potential for developing anti-inflammatory antagonists that could inhibit binding events that are selectin-mediated.

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