Reports

Redundant mechanisms of calcium-induced calcium release underlying calcium waves during fertilization of sea urchin eggs

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Science  16 Jul 1993:
Vol. 261, Issue 5119, pp. 348-352
DOI: 10.1126/science.8392748

Abstract

Propagating Ca2+ waves are a characteristic feature of Ca(2+)-linked signal transduction pathways. Intracellular Ca2+ waves are formed by regenerative stimulation of Ca2+ release from intracellular stores by Ca2+ itself. Mechanisms that rely on either inositol trisphosphate or ryanodine receptor channels have been proposed to account for Ca2+ waves in various cell types. Both channel types contributed to the Ca2+ wave during fertilization of sea urchin eggs. Alternative mechanisms of Ca2+ release imply redundancy but may also allow for modulation and diversity in the generation of Ca2+ waves.