Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Science  13 Aug 1993:
Vol. 261, Issue 5123, pp. 921-923
DOI: 10.1126/science.8346443


The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.

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