Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures

Science  10 Dec 1993:
Vol. 262, Issue 5140, pp. 1718-1721
DOI: 10.1126/science.8259515


Calmodulin is the primary calcium-dependent signal transducer and regulator of a wide variety of essential cellular functions. The structure of calcium-calmodulin bound to the peptide corresponding to the calmodulin-binding domain of brain calmodulin-dependent protein kinase II alpha was determined to 2 angstrom resolution. A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different target enzymes and clarifies the role of calcium in maintaining recognition-competent domain structures.

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