Articles

Vaccine technologies: view to the future

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Science  02 Sep 1994:
Vol. 265, Issue 5177, pp. 1401-1404
DOI: 10.1126/science.7521064

Abstract

The development of vaccines to prevent infectious diseases has been one of the most important contributions of biomedical science. Recent advances in the basic sciences are now fueling the development of a new generation of vaccines that will be based on rational design approaches. Two factors are making this possible: an improved understanding of the microbial factors required for virulence and the nature of the immune response to infection. The status of new vaccine technologies is summarized here.