Reports

Fibroblasts as efficient antigen-presenting cells in lymphoid organs

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Science  02 Jun 1995:
Vol. 268, Issue 5215, pp. 1343-1347
DOI: 10.1126/science.7761853

Abstract

Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.

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