Research NewsImmunology

How the Glucocorticoids Suppress Immunity

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Science  13 Oct 1995:
Vol. 270, Issue 5234, pp. 232-233
DOI: 10.1126/science.270.5234.232

Summary

Glucocorticoids have been used for decades as immune suppressants to treat allergic reactions, reduce inflammation, and prevent rejection of transplanted organs. But how they work has been something of a mystery. Now, two teams of researchers report in Science that they appear to work by stimulating cells to produce a protein, which in turn binds and inactivates a second protein normally involved in turning on genes that orchestrate an immune response.