Research NewsXenotransplantation

New Ways to Avoid Organ Rejection Buoy Hopes

Science  13 Oct 1995:
Vol. 270, Issue 5234, pp. 234-235
DOI: 10.1126/science.270.5234.234


Boston—Researchers reported at a meeting in Boston two promising strategies for preventing the body from rejecting tissue transplanted from another species. One involves treating the transplanted tissue with anti-oxidant drugs to prevent host blood that rushes into the transplant from damaging a key enzyme. The other, more controversial, strategy involves genetically engineering the donor animal to express human immune regulators in its tissues. In theory, tissue from such animals should itself suppress an acute rejection response when it is transplanted into humans.