Research NewsMolecular Biology

Antisense Has Growing Pains

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Science  27 Oct 1995:
Vol. 270, Issue 5236, pp. 575-577
DOI: 10.1126/science.270.5236.575


Antisense compounds once seemed the answer to drug designers' dreams: molecules precisely tailoredto block specific genes. But researchers have run into unexpected difficulties, and they are no longer sure what antisense drugs are doing inside the body. Are clinical trials premature?