Research NewsMolecular Biology

New Clock Gene Cloned

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Science  03 Nov 1995:
Vol. 270, Issue 5237, pp. 732-733
DOI: 10.1126/science.270.5237.732


Organisms from simple, single-celled bacteria to complex mammals have internal biochemical clocks that maintain the daily cycles of behavior known as circadian rhythms. In three reports published in this issue of Science(pp. 805,808, and 811), researchers have cloned a gene called timeless that makes a key protein component of the clock in the fruit fly Drosophila melanogaster. By studying how TIM, the protein made by timeless, cooperates with PER, the protein produced by the only other known fruit fly clock gene, researchers are getting a much clearer picture of the molecular workings of the fly's circadian clock.