Perspective

Muscular Dystrophies—Diseases of the Dystrophin-Glycoprotein Complex

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Science  03 Nov 1995:
Vol. 270, Issue 5237, pp. 755
DOI: 10.1126/science.270.5237.755

Summary

Defects in the gene for the muscle protein dystrophin cause many cases of muscular dystrophy. Worton discusses three new papers, one in this issue of Science (Noguchi et al., p. 819) and two in the November issue of Nature Genetics, which report that defects in the sarcoglycans, transmembrane glycoproteins that associate with dystrophin, underlie certain other types of muscular dystrophy.