Life and Death Decisions: ced-9 and Programmed Cell Death in Caenorhabditis elegans

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Science  10 Nov 1995:
Vol. 270, Issue 5238, pp. 931
DOI: 10.1126/science.270.5238.931


In his grand prize-winning essay for the Pharmacia Biotech & Science Prize for Young Scientists, M. Hengartner discusses the phenomenon of programmed cell death and the gene ced-9 from C. elegans, a small nematode in which the pattern of cell death during development is completely known. The ced-9 gene seems to keep the cell death program off in cells that are scheduled to live.