Perspective

ATP-Sensitive Ksuperscript plus Channels: Paradigm Lost, Paradigm Regained

Science  17 Nov 1995:
Vol. 270, Issue 5239, pp. 1159
DOI: 10.1126/science.270.5239.1159

Summary

In an update of a previous Perspective [L. H. Philipson and D. F. Steiner, Science 268, 372 (1995)], Philipson discusses the molecular basis for Ksubscript ATP, a potassium current that mediates glucose regulation of insulin secretion. A prediction in the previous Perspective is borne out by a paper in this issue of Science (Inagaki et al., p. 1166), which reports the cloning of a new inward rectifier potassium channel and shows that Ksubscript ATP is formed when this channel combines with the sulfonylurea receptor.

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