Role of NK1.1+ T Cells in a TH2 Response and in Immunoglobulin E Production

Science  15 Dec 1995:
Vol. 270, Issue 5243, pp. 1845-1847
DOI: 10.1126/science.270.5243.1845


Immune responses dominated by interleukin-4 (IL-4)-producing T helper type 2 (TH2) cells or by interferon γ (IFN-γ)-producing T helper type 1 (TH1) cells express distinctive protection against infection with different pathogens. Interleukin-4 promotes the differentiation of naïve CD4+ T cells into IL-4 producers and suppresses their development into IFN-γ producers. CD1-specific splenic CD4+NK1.1+ T cells, a numerically minor population, produced IL-4 promptly on in vivo stimulation. This T cell population was essential for the induction of IL-4-producing cells and for switching to immunoglobulin E, an IL-4-dependent event, in response to injection of antibodies to immunoglobulin D.

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