A Docking Receptor for HDL Cholesterol Esters

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Science  26 Jan 1996:
Vol. 271, Issue 5248, pp. 460
DOI: 10.1126/science.271.5248.460


Cholesterol is carried through the blood by low-density lipoprotein (LDL) (“bad” cholesterol) and then into cells by the LDL receptor. In this issue of Science (p. 518), the first receptor for high-density lipoprotein (HDL) (“good” cholesterol) is reported to be the cell-surface protein SR-B1. In his Perspective, D. Steinberg discusses this discovery and describes how the selective uptake of cholesterol mediated by SR-BI delivers cholesterol for steroid hormone synthesis to the liver, the adrenal gland, and the ovary.