Gating by Cyclic AMP: Expanded Role for an Old Signaling Pathway

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Science  26 Jan 1996:
Vol. 271, Issue 5248, pp. 461-463
DOI: 10.1126/science.271.5248.461


The intracellular signal transduction pathway that utilizes cyclic AMP as a key messenger was the first such pathway to be described and has served as a model for many other transducing systems. Now Iyengar illustrates how this classic pathway has yet another function—in a number of different biological systems, the cyclic AMP pathway appears to gate (either negatively or positively) other signal transduction pathways.