BMP-1: Resurrection As Procollagen C-Proteinase

Science  26 Jan 1996:
Vol. 271, Issue 5248, pp. 463
DOI: 10.1126/science.271.5248.463


The characterization of the function of bone morphogenetic protein-1 (BMP-1) was reported in last week's issue of Science (19 January, p. 360). In his Perspective, A. H. Reddi explains why it was surprising (and important) that BMP-1 turned out to be identical to procollagen C-proteinase, the enzyme responsible for triggering the self-assembly of collagen.