Lysosomal Degradation of Ubiquitin-Tagged Receptors

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Science  02 Feb 1996:
Vol. 271, Issue 5249, pp. 617
DOI: 10.1126/science.271.5249.617


Cytosolic proteins are tagged with the polypeptide ubiquitin for eventual destruction by the proteasome. A recent paper in Cell (L. Hicke and H. Riezman, vol. 84, p. 277) shows that in yeast ubiquitin also serves to tag membrane proteins for degradation by proteases in the vacuole, the yeast equivalent of the lysosome.