When Proteins Receive Deadly Messages at Birth

Science  16 Feb 1996:
Vol. 271, Issue 5251, pp. 955-956
DOI: 10.1126/science.271.5251.955


Eukaryotic proteins are tagged for degradation by addition of ubiquitin or single amino acids. Now Jentsch discusses a new prokaryotic protein tagging system reported by Keiler et al. (p. 990) in this issue of Science. In this novel tagging pathway, nascent polypeptides, translated from truncated mRNAs lacking stop codons, receive short COOH-terminal peptide tags encoded by a separate RNA, 10Sa RNA.