The Whole Lactose Repressor

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Science  01 Mar 1996:
Vol. 271, Issue 5253, pp. 1245-1246
DOI: 10.1126/science.271.5253.1245


The lactose repressor turns the bacterial genes for lactose metabolism on and off. This system has served as a blueprint for the study of both eukaryotic and prokaryotic gene regulation for decades. In this issue of Science, the crystal structure of the whole lactose repressor in a complex with DNA and its inducer is reported. In her Perspective, K. Matthews discusses the significance of this landmark event.