Reports

Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

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Science  22 Mar 1996:
Vol. 271, Issue 5256, pp. 1723-1726
DOI: 10.1126/science.271.5256.1723

Abstract

For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.