n-commentPatent Disputes

Clotting Controversy

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Science  29 Mar 1996:
Vol. 271, Issue 5257, pp. 1800
DOI: 10.1126/science.271.5257.1800b


The conflict between Yale University and Corvas International Inc. over hookworm proteins isn't the only item of rancor between the two institutions. An older, but unresolved, fight over the rights to human tissue factor—a protein used to measure anticoagulant effectiveness—has been simmering for years. A Yale researcher claims a scientist affiliated with Corvas used information from a preprint to deduce the protein's cDNA sequence and file a patent; Corvas and the scientist say the work was completely independent. A patent interference claim has been filed with the U.S. Patent and Trademark Office.