Notch and Wingless Signals Collide

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Science  29 Mar 1996:
Vol. 271, Issue 5257, pp. 1822-1823
DOI: 10.1126/science.271.5257.1822


Two important signal transduction pathways for developmental pattern formation in Drosophila are triggered by the binding of the Wingless protein to its receptor and the Delta protein's binding to its receptor Notch. In a paper in this issue of Science (p. 1826), these two pathways are shown to intersect as a result of a physical interaction between Dishevelled, a cytoplasmic protein in the Wingless pathway, and the intracellular COOH-terminus of the Notch protein. In his Perspective, Blair discusses this mutually inhibitory intersection of these two key signaling pathways.