News & CommentGenome Sequencing

Europeans Move On From Yeast to TB

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Science  05 Apr 1996:
Vol. 272, Issue 5258, pp. 27
DOI: 10.1126/science.272.5258.27b


London—Britain's Wellcome Trust has announced plans to pump $2 million into projects aimed at sequencing the genomes of two of the world's biggest killers: Mycobacterium tuberculosis and Plasmodium falciparum, the organisms responsible for tuberculosis and malaria. The announcement coincides with the completion of a European project to sequence the genome of the yeast Saccharomyces cerevisiae. The entire genome of M. tuberculosis should be completed in a year; the P. falciparum project will start with chromosome 3 as a test. Both pose difficult technical challenges because the DNA tends to kink or rearrange during cloning.