Perspectives

No "End of History" for Photolyases

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Science  05 Apr 1996:
Vol. 272, Issue 5258, pp. 48-49
DOI: 10.1126/science.272.5258.48

Summary

In a process called photoreactivation, blue light reverses the chemical damage done to DNA by ultraviolet light. One mediator of this effect is the enzyme CPD photolyase; a second photolyase, (6-4)photolyase, is now reported from Drosophila in a paper in this week's issue (Todo et al., p. 109). In his Perspective, Sancar describes how this discovery defines a family of light-sensitive enzymes that also includes the blue-light receptors of plants and why it represents a reawakening of the photolyase field.