Perspectives

p75NTR: A Receptor After All

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Science  26 Apr 1996:
Vol. 272, Issue 5261, pp. 506-507
DOI: 10.1126/science.272.5261.506

Summary

One of the first growth factor receptors to be cloned, p75NTR was supplanted by newer molecules that bind nerve growth factor (NGF). Now in a number of recent papers, including one in this issue of Science, p75NTR proves to be a receptor for NGF after all, with a specialized function in Schwann's cells. In his Perspective, Bothwell points out that signal transduction by p75NTR is in many ways similar to transduction by the tumor necrosis factor receptors, CD40, and Fas, which couple to both apoptotic cell death and the transcription factor NF-kappaB.