Another Twist to MHC-Peptide Recognition

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Science  17 May 1996:
Vol. 272, Issue 5264, pp. 973-974
DOI: 10.1126/science.272.5264.973


Foreign peptides are displayed on the cell surface in the binding grooves of MHC Class I and II molecules. A new structure of MHC Class II reported in this issue of Science [Fremont et al. (p. 1001)] reveals how these molecules are loaded into their grooves inside the cell. In his Perspective, Wilson describes the picture that this structure and previous structures of MHC molecules is painting about peptide presentation by cells.