Regulating Cell Proliferation--As Easy as APC

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Science  17 May 1996:
Vol. 272, Issue 5264, pp. 974-975
DOI: 10.1126/science.272.5264.974


A report in this week's issue of Science [Rubinfeld et al. (p. 1023)] places the tumor suppressor APC firmly in the signal transduction pathway triggered by WINGLESS (in the fruit fly Drosophila) and WNT (in the mouse). This pathway is a supremely important one for control of cell fate. A second report [Matsumine et al. (p. 1020)] identifies a new downstream target of APC, another tumor suppressor Drosophila discs large (dlg). In his Perspective, Peifer discusses what these findings may mean for how APC participates in cell fate control.