Perspectives

A New Turn (or Two) for Twist

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Science  07 Jun 1996:
Vol. 272, Issue 5267, pp. 1449
DOI: 10.1126/science.272.5267.1449

Summary

Two reports in this week's issue of Science [Baylies (p. 1481) and Spicer (p. 1476)] describe new functions in muscle development for the gene twist, a basic helix-loop-helix transcription factor. In his Perspective, Michelson explains how these two seemingly contradictory functions of twist (specification of mesodermal cell fate in fruit flies and inhibition of muscle differentiation in vertebrates) can be reconciled.