Research NewsBiochemistry

Teams Tackle Protein Prediction

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Science  26 Jul 1996:
Vol. 273, Issue 5274, pp. 426-428
DOI: 10.1126/science.273.5274.426


Computer modelers have been trying for 30 years to predict the three-dimensional structures of proteins from their amino acid sequences. So far, they have had little success. But a novel competition, known as CASP2 (for second Critical Assessment of Techniques for Protein Structure Prediction) could spur the field along. Some 75 groups will pit their models head-to-head to see which do best at coming up with the actual structures of proteins that crystallographers and nuclear magnetic resonance spectroscopists will solve by the end of the year. When the results are discussed at a meeting in December, each group will be able to build on the successful features of their competitors' models, and the competition will become essentially a giant collaboration to crack the problem of protein structure prediction. More information on CASP2 can be found on the Web.