Hormone Mimicry

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Science  26 Jul 1996:
Vol. 273, Issue 5274, pp. 449-450
DOI: 10.1126/science.273.5274.449


Two research articles in this week's Science [Livnah et al. (p. 464) and Wrighton et al. (p. 458)] report the isolation and structure of a 20-amino acid peptide that binds to and activates the receptor for erythropoietin but is not derived from the normal ligand. In his Perspective, Wells describes the unique selection procedure that allowed this accomplishment and what it means for drug development.