The POU Factor Oct-6 and Schwann Cell Differentiation

Science  26 Jul 1996:
Vol. 273, Issue 5274, pp. 507-510
DOI: 10.1126/science.273.5274.507


The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6−/− mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

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