STATs Find That Hanging Together Can Be Stimulating

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Science  09 Aug 1996:
Vol. 273, Issue 5276, pp. 750-751
DOI: 10.1126/science.273.5276.750


A report in this week's issue of Science by Xu et al. (p. 794) shows that homodimers of various kinds of STATs (signal transducers and activators of transcription) bind to regulatory regions of the gene for the interferon-γ gene, each with a slightly different binding site. In their Perspective, Leung, Li, and Stark explain how these cooperating STAT dimers, which interact via their NH2 terminals, can determine the specificity of the cytokine response.