A New Receptor for Growth Hormone-Release Peptide

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Science  16 Aug 1996:
Vol. 273, Issue 5277, pp. 923
DOI: 10.1126/science.273.5277.923


For a decade or so, there have been hints of an alternative way to regulate growth hormone beyond growth hormone-releasing hormone and somatostatin. Now Howard et al., in this week's Science (p. 974), have confirmed this suspicion by cloning the receptor for this alternative pathway. In their Perspective, Conn and Bowers discuss the unusual route by which this receptor was cloned, through the use of “reverse pharmacology” in which a synthetic ligand for the receptor was made before the natural ligand (which still remains unidentified).