Perspectives

Small Nucleolar RNAs Guide Ribosomal RNA Methylation

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Science  23 Aug 1996:
Vol. 273, Issue 5278, pp. 1056-1057
DOI: 10.1126/science.273.5278.1056

Summary

Two recent reports, one in Cell and one in the Journal of Molecular Biology, show that the newly described small nucleolar RNAs control the site of methylation of the ribosomal RNA (rRNA). Tollervey explains how these small RNAs accomplish this targeting and discusses the possible role of this rRNA modification.